Local levonorgestrel regulation of androgen receptor and 17 -hydroxysteroid dehydrogenase type 2 expression in human endometrium | Zendy

Kevin A Burton | Zendy; Teresa A. Henderson | Zendy; Stephen G. Hillier | Zendy; J. Ian Mason | Zendy; Fouad K. Habib | Zendy; Robert Brenner | Zendy; Hilary Critchley | Zendy

Open Access

Local levonorgestrel regulation of androgen receptor and 17 -hydroxysteroid dehydrogenase type 2 expression in human endometrium

Author(s) -

Kevin A Burton,

Teresa A. Henderson,

Stephen G. Hillier,

J. Ian Mason,

Fouad K. Habib,

Robert Brenner,

Hilary Critchley

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg510

Subject(s) - endometrium , levonorgestrel , progesterone receptor , endocrinology , medicine , androgen receptor , estrogen , menstrual cycle , androgen , progestogen , biology , estrogen receptor , andrology , hormone , population , prostate cancer , cancer , family planning , environmental health , breast cancer , research methodology

The levonorgestrel-releasing intrauterine system (LNG-IUS) is a highly effective contraceptive. However, unscheduled breakthrough bleeding (BTB), leads to discontinuation in a proportion of users. The LNG-IUS down-regulates endometrial progesterone and estrogen receptors and this may play a role in the mechanism responsible for BTB. LNG is an androgenic progestogen and so we examined the regulation of the androgen receptor (AR) in endometrium exposed to intrauterine LNG. Furthermore, as the enzyme 17beta-hydroxysteroid dehydrogenase type 2 (17betaHSD2) regulates intracellular levels of estrogens, progestins and androgens, we evaluated the changes in expression of 17betaHSD2 in the same tissue endometrial samples.

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