Inner mitochondrial membrane potential ( m), cytoplasmic ATP content and free Ca2+ levels in metaphase II mouse oocytes | Zendy

Jonathan Van Blerkom | Zendy

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Inner mitochondrial membrane potential ( m), cytoplasmic ATP content and free Ca2+ levels in metaphase II mouse oocytes

Author(s) -

Jonathan Van Blerkom

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg466

Subject(s) - biology , mitochondrion , microbiology and biotechnology , cortical granule , somatic cell , cytoplasm , oocyte , intracellular , metaphase , embryo , medicine , endocrinology , genetics , gene , chromosome

The relative magnitude of the inner mitochondrial membrane potential (DeltaPsim) has been suggested to indicate the competence of mammalian gametes and early embryos. This study examined the response of cultured somatic cells and mouse oocytes to inhibitors and conditions that affect DeltaPsim or metabolism, or both, and measured treatment-specific changes in ATP and cytoplasmic free Ca(2+).

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