Luteal phase dose-response relationships of the antiprogestin CDB-2914 in normally cycling women | Zendy

Maureen Passaro | Zendy

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Luteal phase dose-response relationships of the antiprogestin CDB-2914 in normally cycling women

Author(s) -

Maureen Passaro

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg342

Subject(s) - luteal phase , antiglucocorticoid , endocrinology , luteolysis , mifepristone , medicine , progesterone receptor , corpus luteum , prolactin , receptor , glucocorticoid receptor , follicular phase , hormone , chemistry , biology , estrogen receptor , pregnancy , cancer , breast cancer , genetics

Progesterone receptor modulators have potential therapeutic use in progesterone-dependent conditions such as endometriosis, fibroids and induction of labour. The synthetic steroid CDB-2914 binds to the progesterone and glucocorticoid receptors. In animals it has antiprogestational activity at doses 50-fold less than those required for antiglucocorticoid effects.

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