Efficacy of the swim-up method in eliminating sperm with diminished maturity and aneuploidy | Zendy

Attila Jakab | Zendy

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Efficacy of the swim-up method in eliminating sperm with diminished maturity and aneuploidy

Author(s) -

Attila Jakab

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg288

Subject(s) - sperm , biology , andrology , aneuploidy , fluorescence in situ hybridization , percoll , semen , sperm motility , genetics , chromosome , in vitro , medicine , gene

We have previously shown that after 80% Percoll centrifugation there is an overall 2.7-fold reduction of sperm with chromosomal disomies and diploidies (3.2-fold and 2.0-fold respectively), and of sperm with diminished maturity as detected by cytoplasmic retention. The relationship between disomies and immature sperm was r = 0.7, suggesting that disomy primarily originates in immature sperm. In the present work we studied the efficacy of the swim-up method in elimination of sperm with diminished maturity and with chromosomal aberrations in the swim-up sperm fractions of 10 patients (sperm concentration: 20 +/- 3.9 x 10(6)/ml, range 8.9-45.5; sperm motility: 45.2 +/- 2.4, all mean +/- SEM).

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