Transplantation of intact rat gonads using vascular anastomosis: effects of cryopreservation, ischaemia and genotype | Zendy

Hang Yin | Zendy; Xiang Wang | Zendy; S Samuel Kim | Zendy; Huifang Chen | Zendy; Seang Lin Tan | Zendy; Roger G. Gosden | Zendy

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Transplantation of intact rat gonads using vascular anastomosis: effects of cryopreservation, ischaemia and genotype

Author(s) -

Hang Yin,

Xiang Wang,

S Samuel Kim,

Huifang Chen,

Seang Lin Tan,

Roger G. Gosden

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg236

Subject(s) - transplantation , cryopreservation , biology , fertility preservation , ovary , andrology , ovarian tissue cryopreservation , anastomosis , medicine , endocrinology , surgery , fertility , embryo , population , environmental health , microbiology and biotechnology

A limited store of ovarian follicles is present at birth and its progressive decline during ageing is hastened by alkylating agents and ionizing radiation during treatment for cancer or autoimmune disease. Oligo- or azoospermia can arise for similar reasons in men. There is some experimental evidence showing that targeted gene deletion or drugs to produce hypogonadotrophism can protect germ cells from wastage. Another strategy for conserving fertility is to cryopreserve ovarian or testicular tissue for subsequent transplantation. To maximize gonadal function, it is desirable to preserve whole gonads for transplantation using vascular anastomosis.

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