Pregnancy by the tubal transfer of embryos developed after injection of round spermatids into oocyte cytoplasm of the cynomolgus monkey (Macaca fascicularis) | Zendy

Narumi Ogonuki | Zendy

Open Access

Pregnancy by the tubal transfer of embryos developed after injection of round spermatids into oocyte cytoplasm of the cynomolgus monkey (Macaca fascicularis)

Author(s) -

Narumi Ogonuki

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg212

Subject(s) - spermatid , pronucleus , biology , andrology , embryo , human fertilization , oocyte , sperm , blastocyst , fertilisation , primate , fetus , pregnancy , embryogenesis , anatomy , zygote , reproductive technology , medicine , microbiology and biotechnology , genetics , neuroscience

Round spermatids have been used as substitute gametes in basic reproductive research and in infertility clinics. In humans, however, the efficiency of fertilization and pregnancy is generally much lower after round spermatid injection (ROSI) than after injection with mature sperm. We examined the ability of round spermatids to support embryonic development using a non-human primate as a model. We chose cynomolgus monkeys because, as in humans, their round spermatids have the oocyte-activating capacity of mature sperm.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research