Reproductive semi-cloning respecting biparental origin: Reconstitution of gametes for assisted reproduction | Zendy

Ursula Eichenlaub-Ritter | Zendy

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Reproductive semi-cloning respecting biparental origin: Reconstitution of gametes for assisted reproduction

Author(s) -

Ursula Eichenlaub-Ritter

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg080

Subject(s) - biology , meiosis , cloning (programming) , reproduction , sexual reproduction , gamete , genetics , chromosome segregation , evolutionary biology , fidelity , mitosis , chromosome , computer science , human fertilization , gene , programming language , telecommunications

There are basically two major problems in the genesis of "cloned" gametes in mammals, which have not been addressed in the original debate article. There is no adequate discussion on the mechanisms providing for high fidelity of chromosome segregation in mitosis and meiosis, and for proper imprinting in construction of "reconstituted gametes". The original debate article is uncritical with respect to the currently insufficient database and the incomplete documentation of results.

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