Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome | Zendy

Lourdes Ibáñez | Zendy; Francis de Zegher | Zendy

Open Access

Low-dose combination of flutamide, metformin and an oral contraceptive for non-obese, young women with polycystic ovary syndrome

Author(s) -

Lourdes Ibáñez,

Francis de Zegher

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg056

Subject(s) - flutamide , polycystic ovary , metformin , medicine , endocrinology , population , body mass index , free androgen index , antiandrogen , sex hormone binding globulin , hyperandrogenism , androgen , gynecology , hormone , insulin resistance , obesity , diabetes mellitus , cancer , prostate cancer , androgen receptor , environmental health

The endocrine-metabolic status of non-obese, young women with polycystic ovary syndrome (PCOS) is normalized more effectively by combined treatment with flutamide and metformin than by either of these drugs in monotherapy. In this follow-up study, we assess whether the endocrine-metabolic benefits of combined flutamide-metformin treatment are maintained in the presence of a low-dose oral contraceptive (OC).

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