Open AccessDevelopment and characterization of a long-acting recombinant hFSH agonist
Author(s) -
J. Klein,
Leslie Lobel,
Susan Pollak,
Brandie Lustbader,
R. Todd Ogden,
Michael Sauer,
Joyce W. Lustbader
Publication year - 2003
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deg024
Subject(s) - recombinant dna , agonist , medicine , chemistry , receptor , biochemistry , gene
Fusion of the carboxyterminal peptide (CTP) of hCG to FSH results in a follitropin agonist with an extended half-life, presumably due to the four O-oligosaccharides on the CTP. Alternatively, an rhFSH analogue containing additional N-linked carbohydrate is described in this report.
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