Low-dose antiprogestin treatment prevents pregnancy in rhesus monkeys and is reversible after 1 year of treatment | Zendy

Sherri Borman | Zendy; Kristine M. Schwinof | Zendy; Carlos Niemeyer | Zendy; Kristof Chwalisż | Zendy; Richard L. Stouffer | Zendy; Mary B. Zelinski | Zendy

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Low-dose antiprogestin treatment prevents pregnancy in rhesus monkeys and is reversible after 1 year of treatment

Author(s) -

Sherri Borman,

Kristine M. Schwinof,

Carlos Niemeyer,

Kristof Chwalisż,

Richard L. Stouffer,

Mary B. Zelinski

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deg014

Subject(s) - medicine , pregnancy , fertility , obstetrics , gynecology , gestation , live birth , population , biology , genetics , environmental health

Administration of low doses of an antiprogestin to rhesus monkeys permits ovarian/menstrual cyclicity, suppresses endometrial proliferation and prevents pregnancy without adverse or toxic side-effects after 5-6 months of daily treatment. The purpose of this study was to test the reversibility with respect to restoration of fertility after 1 year of low-dose antiprogestin treatment.

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