Abstracts of the 33rd Annual Meeting of the European Society of Human Reproduction and Embryology

Poster presentation: Implantation and early pregnancyStudy question: Does hysteroscopic polypectomy affect endometrial gene expression in subfertile women? Summary answer: No consistent effect was found in the gene expression in the paired endometrial samples prior to and after polypectomy. What is known already: Endometrial polyps may negatively impact endometrial receptivity through various mechanisms, and surgical removal of the polyps may improve fertility outcome in subfertile patients. Some studies showed that hysteroscopic polypectomy reduces nuclear factor-kappa B expression, increases concentrations of insulin-like growth factor binding protein-1, tumour necrosis factor α and osteopontin in the endometrium. No published study has examined the effect of hysteroscopic polypectomy on global gene expression, and we aimed at studying this