Is estradiol cardioprotection a nitric oxide-mediated effect? | Zendy

A.C. Duncan | Zendy; J. R. Petrie | Zendy; Mark Brosnan | Zendy; Alison M. Devlin | Zendy; Roman Bass | Zendy; D. Stephen CharnockJones | Zendy; J M C Connell | Zendy; Anna F. Dominiczak | Zendy; Mary-Ann Lumsden | Zendy

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Is estradiol cardioprotection a nitric oxide-mediated effect?

Author(s) -

A.C. Duncan,

J. R. Petrie,

Mark Brosnan,

Alison M. Devlin,

Roman Bass,

D. Stephen CharnockJones,

J M C Connell,

Anna F. Dominiczak,

Mary-Ann Lumsden

Publication year - 2002

Publication title -

human reproduction

Language(s) - Hungarian

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/17.7.1918

Subject(s) - enos , nitric oxide , endocrinology , medicine , estrogen , nitric oxide synthase , vasoprotective , endothelium , nitric oxide synthase type iii , fibrinolysis , biology , pharmacology

Estradiol exerts a number of biological effects that support extensive observational data suggesting a protective role for estrogen in cardiovascular disease prevention. These include effects on lipid and carbohydrate metabolism, coagulation/fibrinolysis as well as a possible effect on vascular reactivity. It has been proposed that this might be mediated by vascular endothelial nitric oxide (NO) production. Accordingly, we designed complementary in-vivo and in-vitro studies to investigate this hypothesis further.

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