Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies | Zendy

P. M. Emmer | Zendy

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Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies

Author(s) -

P. M. Emmer

Publication year - 2002

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/17.4.1072

Subject(s) - trophoblast , decidua , placentation , natural killer cell , recurrent miscarriage , biology , hla g , cd16 , immunology , human leukocyte antigen , pregnancy , andrology , miscarriage , immune system , fetus , cytotoxic t cell , medicine , antigen , placenta , cd3 , cd8 , in vitro , biochemistry , genetics

The interaction between decidual natural killer (NK) cells and alloantigens expressed on fetal trophoblast cells are thought to be essential for successful implantation and placentation. Consequently, a disturbed interaction during the first trimester of pregnancy might well lead to a subsequent pregnancy failure.

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