Acute and chronic effects of genistein, tyrphostin and lavendustin A on steroid synthesis in luteinized human granulosa cells | Zendy

S. A. Whitehead | Zendy; Jonathan Cross | Zendy; Christy Burden | Zendy; Michael J. Lacey | Zendy

Open Access

Acute and chronic effects of genistein, tyrphostin and lavendustin A on steroid synthesis in luteinized human granulosa cells

Author(s) -

S. A. Whitehead,

Jonathan Cross,

Christy Burden,

Michael J. Lacey

Publication year - 2002

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/17.3.589

Subject(s) - genistein , androstenedione , estrone , endocrinology , medicine , pregnenolone , aromatase , testosterone (patch) , biology , steroid , estrogen , chemistry , androgen , hormone , cancer , breast cancer

Phytoestrogens, including genistein and other inhibitors of tyrosine kinases (TKs), inhibit specific steroidogenic enzymes. This study was designed to compare the effects of genistein, with two other TK inhibitors, on steroid synthesis in human granulosa luteal (GL) cells and to identify which steroidogenic enzymes they may affect.

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