Preferential location of sex chromosomes, their aneuploidy in human sperm, and their role in determining sex chromosome aneuploidy in embryos after ICSI | Zendy

M. Sbracia | Zendy; Marina Baldi | Zendy; Donglin Cao | Zendy; A Sandrelli | Zendy; A Chiandetti | Zendy; Roberta Poverini | Zendy; C. Aragona | Zendy

Open Access

Preferential location of sex chromosomes, their aneuploidy in human sperm, and their role in determining sex chromosome aneuploidy in embryos after ICSI

Author(s) -

M. Sbracia,

Marina Baldi,

Donglin Cao,

A Sandrelli,

A Chiandetti,

Roberta Poverini,

C. Aragona

Publication year - 2002

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/17.2.320

Subject(s) - aneuploidy , sperm , biology , chromosome , andrology , oligospermia , y chromosome , genetics , male infertility , infertility , medicine , pregnancy , gene

In babies born after ICSI procedures, an increase of de-novo sex chromosome abnormalities has been observed. Several hypotheses have been proposed to explain these findings: an increased rate of sex chromosome aneuploidy in sperm of oligozoospermic men, or a preferential location of the sex chromosomes in the sub-acrosomal region of the sperm nucleus which leads to a reduced DNA decondensation of this region. In order to investigate which theory may be more reliable, we studied the localization of sex chromosomes and their aneuploidy rate in sperm in men undergoing ICSI.

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