Cytotoxic phenotype of intra-epithelial lymphocytes in normal and cryptorchid human testicular excurrent ducts | Zendy

Evgeny Yakirevich | Zendy

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Cytotoxic phenotype of intra-epithelial lymphocytes in normal and cryptorchid human testicular excurrent ducts

Author(s) -

Evgeny Yakirevich

Publication year - 2002

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/17.2.275

Subject(s) - cytotoxic t cell , granzyme b , granzyme , cd8 , biology , epididymis , granzyme a , immunostaining , vas deferens , cd3 , andrology , immunology , immune system , immunohistochemistry , endocrinology , medicine , perforin , sperm , in vitro , biochemistry , botany

Most testicular and epididymal lymphocytes express T-cell markers, but their cytotoxic potential and activation status have not been reported. In this study, distribution of the cytotoxic cells was compared between normal and cryptorchid testes stratified into two groups: the first with complete absence of germ cells [Sertoli cell-only (SCO)] and the second with arrested spermatogenesis (SCA).

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