Open AccessEnhancement of developmental capacity of meiotically inhibited bovine oocytes by retinoic acid
Author(s) -
Paloma Duque
Publication year - 2002
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/17.10.2706
Subject(s) - retinoic acid , chemistry , andrology , oocyte , tretinoin , biology , microbiology and biotechnology , biochemistry , medicine , embryo , gene
Although high vitamin A may be teratogenic to the embryo, retinol has been shown to support oocyte developmental potential in vivo. Similarly, addition of retinol metabolite 9-cis-retinoic acid to in-vitro cultured oocytes could promote cytoplasmic maturation and subsequent early embryonic development. The objective of this study was to evaluate the effects of 5 nmol/l retinoic acid during in-vitro pre-maturation and maturation of bovine oocyte-cumulus complexes.
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