The role of genetic factors in age at natural menopause | Zendy

Jan Peter de Bruin | Zendy; H. Bovenhuis | Zendy; P.A.H. van Noord | Zendy; P. Pearson | Zendy; J.A.M. van Arendonk | Zendy; Egbert R. te Velde | Zendy; W. W. Kuurman | Zendy; M. Dorland | Zendy

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The role of genetic factors in age at natural menopause

Author(s) -

Jan Peter de Bruin,

H. Bovenhuis,

P.A.H. van Noord,

P. Pearson,

J.A.M. van Arendonk,

Egbert R. te Velde,

W. W. Kuurman,

M. Dorland

Publication year - 2001

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/16.9.2014

Subject(s) - menopause , heritability , demography , natural fertility , population , trait , twin study , medicine , obstetrics , biology , gynecology , genetics , family planning , sociology , computer science , research methodology , programming language

Environmental factors explain only a small part of the age variance at which menopause commences. The variation in natural menopause is a trait predominantly determined by interaction of multiple genes, whose identity and causative genetic variation remains to be determined. Menopause is a retrospective marker for the reproductive capacity of preceding years, since subfertility and infertility precede menopause at distinct time-intervals. In the present study we have investigated the contribution of genetic factors to menopausal age.

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