Risk factors for high-order multiple implantation after ovarian stimulation with gonadotrophins: evidence from a large series of 1878 consecutive pregnancies in a single centre | Zendy

Rosa Tur | Zendy; Pedro N. Barri | Zendy; Buenaventura Coroleu | Zendy; Rosario Buxaderas | Zendy; Francisca Martínez | Zendy; Juan Balasch | Zendy

Open Access

Risk factors for high-order multiple implantation after ovarian stimulation with gonadotrophins: evidence from a large series of 1878 consecutive pregnancies in a single centre

Author(s) -

Rosa Tur,

Pedro N. Barri,

Buenaventura Coroleu,

Rosario Buxaderas,

Francisca Martínez,

Juan Balasch

Publication year - 2001

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/16.10.2124

Subject(s) - infertility , ovulation , unexplained infertility , artificial insemination , medicine , pregnancy , insemination , gonadotropin , ovulation induction , receiver operating characteristic , gynecology , luteal phase , univariate analysis , ovarian follicle , in vitro fertilisation , multivariate analysis , obstetrics , biology , ovary , andrology , endocrinology , follicular phase , hormone , sperm , genetics

High-order multiple pregnancies (triplets or more) have a large adverse impact on perinatal morbidity and mortality as well as important economic consequences. Most triplets and higher births are due to ovulation induction alone or in combination with intrauterine insemination (IUI) rather than to in-vitro fertilization (IVF). The present investigation was undertaken to determine whether there were specific variables that related to patient clinical characteristics (age of the woman, duration of infertility, type of infertility, body mass index, basal FSH and LH concentrations), treatment characteristics (initial dose of gonadotrophins, total dose of gonadotrophins administered, number of days of ovarian stimulation, insemination procedure, number of spermatozoa inseminated in patients undergoing IUI, type of luteal support), and ovarian response (oestradiol serum concentrations, number and size of follicles) that might be associated with the occurrence of high-order multiple implantation in order to develop a prediction model.

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