Effect of 6-methylprednisolone on mouse pregnancy rate | Zendy

E. Velilla | Zendy

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Effect of 6-methylprednisolone on mouse pregnancy rate

Author(s) -

E. Velilla

Publication year - 1999

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/14.1.207

Subject(s) - zona pellucida , methylprednisolone , pregnancy , pregnancy rate , zona , embryo , embryo transfer , andrology , blastocyst , medicine , biology , gynecology , embryogenesis , oocyte , immunology , virus , genetics , viral disease , microbiology and biotechnology

The aim of this study was to evaluate the effect of methyl-prednisolone on the pregnancy rate in mice. For this reason, zona pellucida-intact and zona pellucida-free embryos at the blastocyst stage were transferred to recipient mice at day 2.5 of pseudopregnancy. Embryo transfer was performed into non-immunodepressed and immunodepressed groups of recipient mice using 0.3 or 0.6 microgram/g of 6 beta-methylprednisolone. A higher implantation and developmental rate of zona-free embryos transferred to the immunodepressed group of recipients was observed after using the higher dose of methylprednisolone.

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