Intracytoplasmic sperm injection (ICSI) and chromosomally abnormal spermatozoa | Zendy

Pieter In 'T Veld | Zendy; Frank J. Broekmans | Zendy; H. F. de France | Zendy; P. Pearson | Zendy; M.H.E.C. Pieters | Zendy; R. J. van Kooij | Zendy

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Intracytoplasmic sperm injection (ICSI) and chromosomally abnormal spermatozoa

Author(s) -

Pieter In 'T Veld,

Frank J. Broekmans,

H. F. de France,

P. Pearson,

M.H.E.C. Pieters,

R. J. van Kooij

Publication year - 1997

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/12.4.752

Subject(s) - intracytoplasmic sperm injection , aneuploidy , andrology , sperm , biology , male infertility , ploidy , oligospermia , infertility , chromosome , medicine , genetics , pregnancy , gene

An infertile couple was referred for intracytoplasmic sperm injection (ICSI) because of primary infertility and oligoasthenoteratozoospermia (OAT) in the male. It was observed that although the sperm cells presented with an unusual head size and multiple tails they were able to fertilize the oocytes after ICSI. Subsequent molecular cytogenetic analysis demonstrated de-novo chromosome abnormalities in virtually all sperm cells with 40% diploidy and 24% triploidy in addition to aneuploidy for the sex chromosomes.

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