Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection | Zendy

Diane Van Opstal | Zendy; Frans J. Los | Zendy; Sarvan K. Ramlakhan | Zendy; J. O. Van Hemel | Zendy; A M van den Ouweland | Zendy; H. Brandenburg | Zendy; M.H.E.C. Pieters | Zendy; Arie Verhoeff | Zendy; M. Vermeer | Zendy; Marc Dhont | Zendy; Pieter In 'T Veld | Zendy

Open Access

Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection

Author(s) -

Diane Van Opstal,

Frans J. Los,

Sarvan K. Ramlakhan,

J. O. Van Hemel,

A M van den Ouweland,

H. Brandenburg,

M.H.E.C. Pieters,

Arie Verhoeff,

M. Vermeer,

Marc Dhont,

Pieter In 'T Veld

Publication year - 1997

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/12.4.682

Subject(s) - intracytoplasmic sperm injection , andrology , biology , chromosome abnormality , chromosome , aneuploidy , marker chromosome , pregnancy , fetus , karyotype , genetics , gynecology , medicine , in vitro fertilisation , gene

Prenatal cytogenetic analysis of 71 fetuses conceived by intracytoplasmic sperm injection (ICSI) resulted in the detection of nine (12.7%) chromosome aberrations including two cases of 47,XXY, four cases involving a 45,X cell line and three autosomal trisomies. Molecular analysis of the parental origin of the deleted or supernumerary chromosome was performed by using polymorphic microsatellite markers. Six cases involving a sex chromosome abnormality were found to be of paternal origin while the two trisomic cases that could be analysed were of maternal origin. Two cases involved the same infertile couple who had two consecutive ICSI pregnancies terminated because of a chromosome abnormality. The replaced embryos in both cases originated from a single batch of ICSI fertilized oocytes of which part was used to initiate the first pregnancy and part was cryopreserved and used to initiate the second pregnancy.

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