Pathways to understanding the genomic aetiology of osteoarthritis | Zendy

Elena Cibrián–Uhalte | Zendy; J. Mark Wilkinson | Zendy; Lorraine Southam | Zendy; Eleftheria Zeggini | Zendy

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Pathways to understanding the genomic aetiology of osteoarthritis

Author(s) -

Elena Cibrián–Uhalte,

J. Mark Wilkinson,

Lorraine Southam,

Eleftheria Zeggini

Publication year - 2017

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddx302

Subject(s) - biology , disease , osteoarthritis , genomics , underpinning , bioinformatics , etiology , genetics , computational biology , genome , pathology , gene , medicine , alternative medicine , civil engineering , engineering

Osteoarthritis is a common, complex disease with no curative therapy. In this review, we summarize current knowledge on disease aetiopathogenesis and outline genetics and genomics approaches that are helping catalyse a much-needed improved understanding of the biological underpinning of disease development and progression.

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