Open AccessHuman stem cell models of dementia
Author(s) -
Frederick J. Livesey
Publication year - 2014
Publication title -
human molecular genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.811
H-Index - 276
eISSN - 1460-2083
pISSN - 0964-6906
DOI - 10.1093/hmg/ddu302
Subject(s) - biology , induced pluripotent stem cell , dementia , neuroscience , stem cell , computational biology , microbiology and biotechnology , genetics , disease , pathology , gene , embryonic stem cell , medicine
Positive predictions were made in the aftermath of the development of induced pluripotent stem cell technology for the use of patient-specific iPSCs to model neurological diseases, including dementia. Here, we review the current state of the field and explore how close we are to the goal of in vitro models that capture all aspects of the cell and molecular biology of dementia.
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