Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease | Zendy

Beate Winner | Zendy; Maria C. Marchetto | Zendy; Jürgen Winkler | Zendy; Fred H. Gage | Zendy

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Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease

Author(s) -

Beate Winner,

Maria C. Marchetto,

Jürgen Winkler,

Fred H. Gage

Publication year - 2014

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddu205

Subject(s) - motor neuron , amyotrophic lateral sclerosis , hereditary spastic paraplegia , neuroscience , induced pluripotent stem cell , biology , disease , spinal muscular atrophy , neuron , human induced pluripotent stem cells , upper motor neuron , phenotype , spinal cord , pathology , medicine , embryonic stem cell , genetics , gene

While motor neuron diseases are currently incurable, induced pluripotent stem cell research has uncovered some disease-relevant phenotypes. We will discuss strategies to model different aspects of motor neuron disease and the specific neurons involved in the disease. We will then describe recent progress to investigate common forms of motor neuron disease: amyotrophic lateral sclerosis, hereditary spastic paraplegia and spinal muscular atrophy.

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