Genetic and epigenetic contribution to complex traits | Zendy

Helena Kilpinen | Zendy; Emmanouil T. Dermitzakis | Zendy

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Genetic and epigenetic contribution to complex traits

Author(s) -

Helena Kilpinen,

Emmanouil T. Dermitzakis

Publication year - 2012

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/dds383

Subject(s) - biology , epigenome , epigenetics , genomics , genetics , computational biology , functional genomics , dna sequencing , genome , phenotype , human genetics , human genetic variation , human genome , genetic variation , population genomics , context (archaeology) , inheritance (genetic algorithm) , dna methylation , gene , gene expression , paleontology

Much of the recent advances in functional genomics owe to developments in next-generation sequencing technology, which has contributed to the exponential increase of genomic data available for different human disease and population samples. With functional sequencing assays available to query both the transcriptome and the epigenome, annotation of the non-coding, regulatory genome is steadily improving and providing means to interpret the functional consequences of genetic variants associated with human complex traits. This has highlighted the need to better understand the normal variation in various cellular phenotypes, such as epigenetic modifications, and their transgenerational inheritance. In this review, we discuss different aspects of epigenetic variation in the context of DNA sequence variation and its contribution to complex phenotypes.

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