Cancer genetics of epigenetic genes | Zendy

Ahmad Miremadi | Zendy; Mikkel Z. Oestergaard | Zendy; Paul D.P. Pharoah | Zendy; Carlos Caldas | Zendy

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Cancer genetics of epigenetic genes

Author(s) -

Ahmad Miremadi,

Mikkel Z. Oestergaard,

Paul D.P. Pharoah,

Carlos Caldas

Publication year - 2007

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddm021

Subject(s) - biology , epigenome , cancer epigenetics , epigenetics , histone methyltransferase , epigenomics , genetics , histone , histone acetyltransferases , histone methylation , chromatin , dna methylation , histone code , methyltransferase , epigenetics of physical exercise , histone h2a , gene , methylation , gene expression , nucleosome

The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.

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