Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis | Zendy

Howard J. Edenberg | Zendy; Xiaoling Xuei | Zendy; Hui-Ju Chen | Zendy; Huijun Tian | Zendy; Leah Wetherill | Zendy; Danielle M. Dick | Zendy; Laura Almasy | Zendy; Laura J. Bierut | Zendy; Kathleen K. Bucholz | Zendy; Alison Goate | Zendy; Victor Hesselbrock | Zendy; Samuel Kuperman | Zendy; John I. Nürnberger | Zendy; Bernice Porjesz | Zendy; John P. Rice | Zendy; Marc A. Schuckit | Zendy; Jay A. Tischfield | Zendy; Henri Begleiter | Zendy; Tatiana Foroud | Zendy

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Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis

Author(s) -

Howard J. Edenberg,

Xiaoling Xuei,

Hui-Ju Chen,

Huijun Tian,

Leah Wetherill,

Danielle M. Dick,

Laura Almasy,

Laura J. Bierut,

Kathleen K. Bucholz,

Alison Goate,

Victor Hesselbrock,

Samuel Kuperman,

John I. Nürnberger,

Bernice Porjesz,

John P. Rice,

Marc A. Schuckit,

Jay A. Tischfield,

Henri Begleiter,

Tatiana Foroud

Publication year - 2006

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddl073

Subject(s) - adh1b , haplotype , single nucleotide polymorphism , biology , genetics , linkage disequilibrium , alcohol dehydrogenase , genetic association , allele , gene , alcohol dependence , candidate gene , genotype , alcohol , dehydrogenase , branched chain alpha keto acid dehydrogenase complex , biochemistry , enzyme

Linkage evidence indicated that gene(s) located on chromosome 4q, in the region of the alcohol dehydrogenase (ADH) genes, affected risk for alcoholism. We genotyped 110 single nucleotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism in a set of families with multiple alcoholic members, using the pedigree disequilibrium test. There was strong evidence that variations in ADH4 are associated with alcoholism: 12 SNPs were significantly associated. The region of strongest association ran from intron 1 to 19.5 kb beyond the 3' end of the gene. Haplotype tag SNPs were selected for the block in the ADH4 gene that provided evidence of association and subsequently used in association analysis; the haplotype was significantly associated with alcoholism (P=0.01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk. Among African-Americans, there was evidence that the ADH1B*3 allele was protective.

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