Genetic variation in DTNBP1 influences general cognitive ability | Zendy

Katherine E. Burdick | Zendy; Todd Lencz | Zendy; Birgit Funke | Zendy; Christine Finn | Zendy; Philip R. Szeszko | Zendy; John M. Kane | Zendy; Raju Kucherlapati | Zendy; Anil K. Malhotra | Zendy

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Genetic variation in DTNBP1 influences general cognitive ability

Author(s) -

Katherine E. Burdick,

Todd Lencz,

Birgit Funke,

Christine Finn,

Philip R. Szeszko,

John M. Kane,

Raju Kucherlapati,

Anil K. Malhotra

Publication year - 2006

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddi481

Subject(s) - biology , schizophrenia (object oriented programming) , cognition , genetic linkage , linkage (software) , genetics , genetic variation , trait , chromosome , variation (astronomy) , gene , psychology , neuroscience , psychiatry , computer science , programming language , physics , astrophysics

Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.

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