Camels and zebrafish, viruses and cancer: a microRNA update | Zendy

Eugène Berezikov | Zendy; Ronald H.A. Plasterk | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Camels and zebrafish, viruses and cancer: a microRNA update

Author(s) -

Eugène Berezikov,

Ronald H.A. Plasterk

Publication year - 2005

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddi271

Subject(s) - biology , microrna , zebrafish , gene , computational biology , genetics , regulation of gene expression , drosha , gene expression , genomics , genome , rna interference , rna

MicroRNAs (miRNAs) form an extensive class of RNA molecules that regulate gene expression at post-transcriptional level. In recent years, much progress has been made in dissection of biogenesis and functions of miRNAs. There are at least several hundred miRNA genes in the human genome, and the emerging evidence suggests that miRNAs are broadly implicated in gene regulation. Here, we review some recent advances, and particularly we discuss how comparative genomics helps to identify novel miRNA genes, how studies in zebrafish reveal roles of miRNAs in morphogenesis, how changes in miRNA expression patterns are connected with cancer and how host-virus coevolution exploits miRNA regulatory pathways.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research