Foxl2 is required for commitment to ovary differentiation | Zendy

Chris Ottolenghi | Zendy; Shakib Omari | Zendy; José Elías GarcíaOrtíz | Zendy; Manuela Uda | Zendy; Laura Crisponi | Zendy; Antonino Forabosco | Zendy; Giuseppe Pilia | Zendy; David Schlessinger | Zendy

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Foxl2 is required for commitment to ovary differentiation

Author(s) -

Chris Ottolenghi,

Shakib Omari,

José Elías GarcíaOrtíz,

Manuela Uda,

Laura Crisponi,

Antonino Forabosco,

Giuseppe Pilia,

David Schlessinger

Publication year - 2005

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddi210

Subject(s) - biology , gonad , ovary , sexual differentiation , somatic cell , prophase , gene , meiosis , genetics , transcription factor , development of the gonads , function (biology) , endocrinology

Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.

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