How a Hedgehog might see holoprosencephaly | Zendy

Erich Roessler | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

How a Hedgehog might see holoprosencephaly

Author(s) -

Erich Roessler

Publication year - 2003

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddg058

Subject(s) - holoprosencephaly , biology , sonic hedgehog , context (archaeology) , hedgehog , forebrain , evolutionary biology , hedgehog signaling pathway , vertebrate , genetics , neuroscience , fetus , signal transduction , pregnancy , gene , central nervous system , paleontology

Detailed knowledge of the Hedgehog signaling pathway is fundamental to an understanding of vertebrate development as well as several birth defects in humans. Here we review various aspects of Hedgehog synthesis, secretion, distribution and function in the context of the most common anomaly of the developing forebrain in humans, holoprosencephaly. Genetic studies in numerous model organisms are beginning to elucidate the factors that are likely candidates for the causes of early embryonic defects in humans, including holoprosencephaly.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research