Loss of epigenetic polarity is a hallmark of hematopoietic stem cell aging | Zendy

Eva Mejía-Ramírez | Zendy; Hartmut Geiger | Zendy; Maria Carolina Florian | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Loss of epigenetic polarity is a hallmark of hematopoietic stem cell aging

Author(s) -

Eva Mejía-Ramírez,

Hartmut Geiger,

Maria Carolina Florian

Publication year - 2020

Publication title -

human molecular genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.811

H-Index - 276

eISSN - 1460-2083

pISSN - 0964-6906

DOI - 10.1093/hmg/ddaa189

Subject(s) - stem cell , biology , stem cell theory of aging , epigenetics , microbiology and biotechnology , polarity (international relations) , haematopoiesis , adult stem cell , somatic cell , hematopoietic stem cell , cellular differentiation , genetics , cell , stem cell factor , gene

Changes of polarity in somatic stem cells upon aging or disease lead to a functional deterioration of stem cells and consequently loss of tissue homeostasis, likely due to changes in the mode (symmetry versus asymmetry) of stem cell divisions. Changes in polarity of epigenetic markers (or ‘epi-polarity’) in stem cells, which are linked to alterations in chromatin architecture, might explain how a decline in the frequency of epipolar stem cells can have a long-lasting impact on the function of especially aging stem cells. The drift in epipolarity might represent a novel therapeutic target to improve stem cell function upon aging or disease. Here we review basic biological principles of epigenetic polarity, with a special focus on epipolarity and aging of hematopoietic stem cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research