PathwayMatcher: proteoform-centric network construction enables fine-granularity multiomics pathway mapping
Author(s) -
Luis Francisco Hernández Sánchez,
Bram Burger,
Carlos Horro,
Antonio Fabregat,
Stefan Johansson,
Pål R. Njølstad,
Harald Barsnes,
Henning Hermjakob,
Marc Vaudel
Publication year - 2019
Publication title -
gigascience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.947
H-Index - 54
ISSN - 2047-217X
DOI - 10.1093/gigascience/giz088
Subject(s) - granularity , computational biology , computer science , data science , biology , operating system
Mapping biomedical data to functional knowledge is an essential task in bioinformatics and can be achieved by querying identifiers (e.g., gene sets) in pathway knowledge bases. However, the isoform and posttranslational modification states of proteins are lost when converting input and pathways into gene-centric lists.
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