Fast and accurate relatedness estimation from high-throughput sequencing data in the presence of inbreeding
Author(s) -
Kristian Hanghøj,
Ida Moltke,
Philip Alstrup Andersen,
Andrea Manica,
Thorfinn Sand Korneliussen
Publication year - 2019
Publication title -
gigascience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.947
H-Index - 54
ISSN - 2047-217X
DOI - 10.1093/gigascience/giz034
Subject(s) - inbreeding , computer science , raw data , estimation , throughput , statistics , data mining , mathematics , engineering , telecommunications , population , demography , systems engineering , sociology , wireless , programming language
The estimation of relatedness between pairs of possibly inbred individuals from high-throughput sequencing (HTS) data has previously not been possible for samples where we cannot obtain reliable genotype calls, as in the case of low-coverage data.
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