Advances in genomic hepatocellular carcinoma research | Zendy

Weitai Huang | Zendy; Anders J. Skanderup | Zendy; Caroline Lee | Zendy

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Advances in genomic hepatocellular carcinoma research

Author(s) -

Weitai Huang,

Anders J. Skanderup,

Caroline Lee

Publication year - 2018

Publication title -

gigascience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.947

H-Index - 54

ISSN - 2047-217X

DOI - 10.1093/gigascience/giy135

Subject(s) - hepatocellular carcinoma , computational biology , biology , somatic cell , carcinogenesis , genome , exome sequencing , precision medicine , bioinformatics , cancer , gene , mutation , genetics

Hepatocellular carcinoma (HCC) is the cancer with the second highest mortality in the world due to its late presentation and limited treatment options. As such, there is an urgent need to identify novel biomarkers for early diagnosis and to develop novel therapies. The availability of next-generation sequencing (NGS) data from tumors of liver cancer patients has provided us with invaluable resources to better understand HCC through the integration of data from different sources to facilitate the identification of promising biomarkers or therapeutic targets.

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