Fast-SG: an alignment-free algorithm for hybrid assembly | Zendy

Alex Di Genova | Zendy; Gonzalo A. Ruz | Zendy; Marie-France Sagot | Zendy; Alejandro Maass | Zendy

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Fast-SG: an alignment-free algorithm for hybrid assembly

Author(s) -

Alex Di Genova,

Gonzalo A. Ruz,

Marie-France Sagot,

Alejandro Maass

Publication year - 2018

Publication title -

gigascience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.947

H-Index - 54

ISSN - 2047-217X

DOI - 10.1093/gigascience/giy048

Subject(s) - software portability , computer science , sequence assembly , hybrid genome assembly , modular design , reuse , genome , graph , algorithm , range (aeronautics) , theoretical computer science , reference genome , biology , programming language , ecology , biochemistry , gene expression , materials science , transcriptome , composite material , gene

Long-read sequencing technologies are the ultimate solution for genome repeats, allowing near reference-level reconstructions of large genomes. However, long-read de novo assembly pipelines are computationally intense and require a considerable amount of coverage, thereby hindering their broad application to the assembly of large genomes. Alternatively, hybrid assembly methods that combine short- and long-read sequencing technologies can reduce the time and cost required to produce de novo assemblies of large genomes.

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