G-Anchor: a novel approach for whole-genome comparative mapping utilizing evolutionary conserved DNA sequences | Zendy

Vasileios Lenis | Zendy; Martin Swain | Zendy; Denis M. Larkin | Zendy

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G-Anchor: a novel approach for whole-genome comparative mapping utilizing evolutionary conserved DNA sequences

Author(s) -

Vasileios Lenis,

Martin Swain,

Denis M. Larkin

Publication year - 2018

Publication title -

gigascience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.947

H-Index - 54

ISSN - 2047-217X

DOI - 10.1093/gigascience/giy017

Subject(s) - genome , reference genome , computational biology , biology , comparative genomics , genome project , genetics , genome evolution , genome browser , genomics , gene

Cross-species whole-genome sequence alignment is a critical first step for genome comparative analyses, ranging from the detection of sequence variants to studies of chromosome evolution. Animal genomes are large and complex, and whole-genome alignment is a computationally intense process, requiring expensive high-performance computing systems due to the need to explore extensive local alignments. With hundreds of sequenced animal genomes available from multiple projects, there is an increasing demand for genome comparative analyses.

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