Piggy: a rapid, large-scale pan-genome analysis tool for intergenic regions in bacteria | Zendy

Harry A. Thorpe | Zendy; Sion Bayliss | Zendy; Samuel K. Sheppard | Zendy; Edward J. Feil | Zendy

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Piggy: a rapid, large-scale pan-genome analysis tool for intergenic regions in bacteria

Author(s) -

Harry A. Thorpe,

Sion Bayliss,

Samuel K. Sheppard,

Edward J. Feil

Publication year - 2018

Publication title -

gigascience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.947

H-Index - 54

ISSN - 2047-217X

DOI - 10.1093/gigascience/giy015

Subject(s) - intergenic region , computational biology , genome , scale (ratio) , bacteria , ribosomal intergenic spacer analysis , biology , genetics , gene , geography , phylogenetics , cartography , ribosomal dna

The concept of the "pan-genome," which refers to the total complement of genes within a given sample or species, is well established in bacterial genomics. Rapid and scalable pipelines are available for managing and interpreting pan-genomes from large batches of annotated assemblies. However, despite overwhelming evidence that variation in intergenic regions in bacteria can directly influence phenotypes, most current approaches for analyzing pan-genomes focus exclusively on protein-coding sequences.

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