Open AccessMesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations
Author(s) -
Mengni Liu,
Jianyu Chen,
Xin Wang,
Chengwei Wang,
Xiaolong Zhang,
Yubin Xie,
Zhixiang Zuo,
Jian Ren,
Qi Zhao
Publication year - 2021
Publication title -
gigascience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.947
H-Index - 54
ISSN - 2047-217X
DOI - 10.1093/gigascience/giab036
Subject(s) - bioconductor , computational biology , phylogenetic tree , computer science , inference , biology , bioinformatics , genetics , artificial intelligence , gene
Multi-region sequencing (MRS) has been widely used to analyze intra-tumor heterogeneity (ITH) and cancer evolution. However, comprehensive analysis of mutational data from MRS is still challenging, necessitating complicated integration of a plethora of computational and statistical approaches.
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