High-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth | Zendy

Chun-Te Chiang | Zendy; Roy Lau | Zendy; Ahmadreza Ghaffarizadeh | Zendy; Matthew Brovold | Zendy; Dipen Vyas | Zendy; Edwin F. Juarez | Zendy; Anthony Atala | Zendy; David B. Agus | Zendy; Shay Söker | Zendy; Paul Macklin | Zendy; Daniel Ruderman | Zendy; Shan M. Mumenthaler | Zendy

Open Access

High-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth

Author(s) -

Chun-Te Chiang,

Roy Lau,

Ahmadreza Ghaffarizadeh,

Matthew Brovold,

Dipen Vyas,

Edwin F. Juarez,

Anthony Atala,

David B. Agus,

Shay Söker,

Paul Macklin,

Daniel Ruderman,

Shan M. Mumenthaler

Publication year - 2021

Publication title -

gigascience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.947

H-Index - 54

ISSN - 2047-217X

DOI - 10.1093/gigascience/giab026

Subject(s) - tumor microenvironment , extracellular matrix , metastasis , colorectal cancer , cancer cell , cancer research , cell growth , biology , desmoplasia , stroma , cancer , microbiology and biotechnology , chemistry , immunology , biochemistry , tumor cells , genetics , immunohistochemistry

Colorectal cancer (CRC) mortality is principally due to metastatic disease, with the most frequent organ of metastasis being the liver. Biochemical and mechanical factors residing in the tumor microenvironment are considered to play a pivotal role in metastatic growth and response to therapy. However, it is difficult to study the tumor microenvironment systematically owing to a lack of fully controlled model systems that can be investigated in rigorous detail.

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