TGS-GapCloser: A fast and accurate gap closer for large genomes with low coverage of error-prone long reads | Zendy

Mengyang Xu | Zendy; Lidong Guo | Zendy; Shengqiang Gu | Zendy; Ou Wang | Zendy; Rui Zhang | Zendy; Brock A. Peters | Zendy; Guangyi Fan | Zendy; Xin Liu | Zendy; Xun Xu | Zendy; Li Deng | Zendy; YongWei Zhang | Zendy

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TGS-GapCloser: A fast and accurate gap closer for large genomes with low coverage of error-prone long reads

Author(s) -

Mengyang Xu,

Lidong Guo,

Shengqiang Gu,

Ou Wang,

Rui Zhang,

Brock A. Peters,

Guangyi Fan,

Xin Liu,

Xun Xu,

Li Deng,

YongWei Zhang

Publication year - 2020

Publication title -

gigascience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.947

H-Index - 54

ISSN - 2047-217X

DOI - 10.1093/gigascience/giaa094

Subject(s) - contig , genome , reference genome , sequence assembly , nanopore sequencing , computer science , computational biology , whole genome sequencing , algorithm , data mining , biology , genetics , gene , gene expression , transcriptome

Analyses that use genome assemblies are critically affected by the contiguity, completeness, and accuracy of those assemblies. In recent years single-molecule sequencing techniques generating long-read information have become available and enabled substantial improvement in contig length and genome completeness, especially for large genomes (>100 Mb), although bioinformatic tools for these applications are still limited.

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