Open AccessAn improved pig reference genome sequence to enable pig genetics and genomics research
Author(s) -
Amanda Warr,
Nabeel A. Affara,
Bronwen Aken,
Hamid Beiki,
Derek M. Bickhart,
Konstantinos Billis,
William Chow,
Lél Eöry,
Heather Finlayson,
Paul Flicek,
Carlos García Girón,
Darren K. Griffin,
Richard Hall,
Greg Hannum,
Thibaut Hourlier,
Kerstin Howe,
David Hume,
Osagie Izuogu,
Kristi Kim,
Sergey Koren,
Haibo Liu,
Nancy Manchanda,
Fergal J. Martin,
Dan neman,
Rebecca E. O’Connor,
Adam M. Phillippy,
G. A. Rohrer,
Benjamin D. Rosen,
Laurie A. Rund,
Carole A. Sargent,
Lawrence B. Schook,
Steven Schroeder,
Ariel Schwartz,
Benjamin M. Skinner,
Richard Talbot,
Elizabeth Tseng,
Christopher K. Tuggle,
Mick Watson,
Timothy P. L. Smith,
Alan Archibald
Publication year - 2020
Publication title -
gigascience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.947
H-Index - 54
ISSN - 2047-217X
DOI - 10.1093/gigascience/giaa051
Subject(s) - genome , reference genome , biology , genome project , genomics , computational biology , sequence assembly , whole genome sequencing , genetics , shotgun sequencing , gene , gene expression , transcriptome
The domestic pig (Sus scrofa) is important both as a food source and as a biomedical model given its similarity in size, anatomy, physiology, metabolism, pathology, and pharmacology to humans. The draft reference genome (Sscrofa10.2) of a purebred Duroc female pig established using older clone-based sequencing methods was incomplete, and unresolved redundancies, short-range order and orientation errors, and associated misassembled genes limited its utility.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom