Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats | Zendy

Gerald L. Coleman | Zendy; Stephen W. Barthold | Zendy; G. W. Osbaldiston | Zendy; Shan Foster | Zendy; A. M. Jonas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats

Author(s) -

Gerald L. Coleman,

Stephen W. Barthold,

G. W. Osbaldiston,

Shan Foster,

A. M. Jonas

Publication year - 1977

Publication title -

journal of gerontology

Language(s) - Uncategorized

Resource type - Journals

eISSN - 2331-3323

pISSN - 0022-1422

DOI - 10.1093/geronj/32.3.258

Subject(s) - pathological , physiology , incidence (geometry) , pathology , disease , medicine , mycoplasma , biology , microbiology and biotechnology , physics , optics

Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age, while alpha-1 globulin and cholesterol increased.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research