Epigenetics, Heredity, and Aging | Zendy

Eric Lieberman Greer | Zendy

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Epigenetics, Heredity, and Aging

Author(s) -

Eric Lieberman Greer

Publication year - 2020

Publication title -

innovation in aging

Language(s) - English

Resource type - Journals

ISSN - 2399-5300

DOI - 10.1093/geroni/igaa057.2619

Subject(s) - longevity , epigenetics , biology , heredity , caenorhabditis elegans , transgenerational epigenetics , phenotype , genetics , chromatin , evolutionary biology , gene

Longevity has long been shown to be regulated by genetic and environmental factors. We recently showed that longevity in the nematode Caenorhabditis elegans can also be regulated by the transmission of epigenetic information. We have shown that several chromatin modifying enzymes have a transgenerational non-Mendellian effect in worms on the longevity of their descendants. I will discuss some of our recent work attempting to decipher how epigenetic modifications can regulate complex phenotypes, including longevity, and how this non-genetic information can be transmitted across generations.

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