Open AccessMitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults
Author(s) -
Gregory J. Tranah,
Kristine Yaffe,
Shana M. Katzman,
Ernest T. Lam,
Ludmila Pawlikowska,
PuiYan Kwok,
Nicholas J. Schork,
Todd M. Manini,
Stephen B. Kritchevsky,
Fridtjof Thomas,
Anne B. Newman,
Tamara B. Harris,
Anne L. Coleman,
Michael B. Gorin,
Elizabeth Helzner,
Michael C. Rowbotham,
Warren S. Browner,
Steven R. Cummings
Publication year - 2015
Publication title -
the journals of gerontology series a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.134
H-Index - 189
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glv097
Subject(s) - heteroplasmy , mitochondrial dna , disease , genetics , biology , medicine , gene
Mitochondrial DNA (mtDNA) heteroplasmy is a mixture of normal and mutated mtDNA molecules in a cell. High levels of heteroplasmy at specific mtDNA sites lead to inherited mitochondrial diseases with neurological, sensory, and movement impairments. Here we test the hypothesis that heteroplasmy levels in elderly adults are associated with impaired function resembling mild forms of mitochondrial disease.
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