Open AccessParadoxical Associations of Insulin Resistance With Total and Cardiovascular Mortality in Humans
Author(s) -
Ki Su Kim,
Yu Mi Lee,
In Kyu Lee,
Dae Jung Kim,
David R. Jacobs,
Dong Hoon Lee
Publication year - 2014
Publication title -
the journals of gerontology. series a, biological sciences and medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.134
H-Index - 189
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/glu194
Subject(s) - insulin resistance , medicine , obesity , insulin , hazard ratio , homeostasis , endocrinology , physiology , confidence interval
Insulin resistance is linked to many human chronic diseases. Paradoxically, however, impaired insulin signaling contributes to longevity in various organisms and is suggested as an adaptive mechanism against external stressors, including obesity. We formulated a novel hypothesis that insulin resistance can be beneficial in obese humans, insofar as it does not cause glucose dysmetabolism.