The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances | Zendy

Zoltán Ungvári | Zendy; Anna Csiszár | Zendy

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The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances

Author(s) -

Zoltán Ungvári,

Anna Csiszár

Publication year - 2012

Publication title -

the journals of gerontology series a

Language(s) - English

Resource type - Journals

eISSN - 1758-535X

pISSN - 1079-5006

DOI - 10.1093/gerona/gls072

Subject(s) - paracrine signalling , endocrine system , medicine , pathophysiology , heart failure , insulin like growth factor , oxidative stress , bioinformatics , growth factor , endocrinology , neuroscience , biology , hormone , receptor

This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1, provides a landscape of molecular mechanisms involved in cardiovascular alterations in patients and animal models with congenital and adult-onset IGF-1 deficiency, and explores the link between age-related IGF-1 deficiency and the molecular, cellular, and functional changes that occur in the cardiovascular system during aging. Microvascular protection conferred by endocrine and paracrine IGF-1 signaling, its implications for the pathophysiology of cardiac failure and vascular cognitive impairment, and the role of impaired cellular stress resistance in cardiovascular aging considered here are based on emerging knowledge of the effects of IGF-1 on Nrf2-driven antioxidant response.

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