Interleukin-18 Polymorphism and Physical Functioning in Older People: A Replication Study and Meta-Analysis | Zendy

Kyla H Thomas | Zendy; Sajjad Rafiq | Zendy; Timothy M. Frayling | Zendy; Shah Ebrahim | Zendy; Meena Kumari | Zendy; J. Gallacher | Zendy; Luigi Ferrucci | Zendy; Stefania Bandinelli | Zendy; Robert B. Wallace | Zendy; David Melzer | Zendy; Richard M. Martin | Zendy; Yoav BenShlomo | Zendy

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Interleukin-18 Polymorphism and Physical Functioning in Older People: A Replication Study and Meta-Analysis

Author(s) -

Kyla H Thomas,

Sajjad Rafiq,

Timothy M. Frayling,

Shah Ebrahim,

Meena Kumari,

J. Gallacher,

Luigi Ferrucci,

Stefania Bandinelli,

Robert B. Wallace,

David Melzer,

Richard M. Martin,

Yoav BenShlomo

Publication year - 2009

Publication title -

the journals of gerontology series a

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.134

H-Index - 189

eISSN - 1758-535X

pISSN - 1079-5006

DOI - 10.1093/gerona/glp092

Subject(s) - confidence interval , meta analysis , linear regression , demography , polymorphism (computer science) , gerontology , allele , medicine , replicate , psychology , genetics , biology , gene , statistics , mathematics , sociology

Levels of the proinflammatory cytokine interleukin-18 (IL-18) are raised in old age and are associated with reduced physical functioning. Previous studies have indicated that the C allele of the rs5744256 polymorphism in the IL-18 gene is strongly associated with reduced circulating IL-18 levels. This variant has previously been associated with improved locomotor performance in old age, but the finding requires independent replication.

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