Open AccessWhite Blood Cell Counts, Insulinlike Growth Factor-1 Levels, and Frailty in Community-Dwelling Older Women
Author(s) -
S. X. Leng,
Wei-Hung Hung,
Anne Rentoumis Cappola,
Qilu Yu,
QianLi Xue,
L. P. Fried
Publication year - 2009
Publication title -
the journals of gerontology series a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.134
H-Index - 189
eISSN - 1758-535X
pISSN - 1079-5006
DOI - 10.1093/gerona/gln047
Subject(s) - white blood cell , insulin like growth factor , medicine , receptor , growth factor , endocrinology , white (mutation) , biology , gene , genetics
Elevated white blood cell (WBC) counts and decreased insulin-like growth factor-1 (IGF-1) levels are individually associated with frailty in older adults. WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated.
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